Molecular, Cell, Development (MCD) Seminar Series - McMaster University
2008-09 || 2009-10 || 2010-11 || 2011-12 || 2012-13

Molecular, Cell, Development (MCD) SEMINAR SERIES
Department of Biology


 
Speaker: Dr. Pamela Cowin

Date: Friday 8th, March, 2013
Time: 12 noon
Location: HSC 1A5

Title: Novel markers of the Mammary Lineage

Abstract
My group uses genetic approaches to study Wnt and Hedgehog signaling during the embryonic and postnatal mammary development. Both of these pathways play important roles in the regulation of mammary stem/progenitor cell proliferation as well as multiple cell-fate decisions in the mammary lineage. They also play critical roles in inducing mammary tumor onset and promoting tumor progression through amplification and stromal support of stem and early mammary progenitor cell populations. Currently there is a dearth of specific markers for the mammary lineage and their identification is likely to illuminate not only normal mammary developmental processes but also to have diagnostic utility in determining the cell of origin of breast cancer subtypes. To this end we have studied the ability of a novel GPCR and latent TGFbeta-binding protein to identify mammary stem cells and specific luminal subpopulations respectively.