Molecular, Cell, Development (MCD) Seminar Series - McMaster University
2008-09 || 2009-10 || 2010-11 || 2011-12 || 2012-13

Molecular, Cell, Development (MCD) SEMINAR SERIES
Department of Biology


 
Speaker: Dr. Trevor Williams (University of Colorado Denver)

Date: Friday, December 7th, 2012
Time: 12 noon
Location: HSC 1A5

Title: Cross-talk between transcription factors and signaling molecules in development of the mammalian face and limbs

Abstract
Research in the Williams’ laboratory is focused on understanding the genetic hierarchy responsible for mammalian embryonic development using a combination of mouse molecular genetics, bioinformatics, cell biology, and molecular biology approaches. Our long terms goals are aimed at elucidating the structure, function, and regulation of the AP-2 family of transcription factors – genes that are vital for normal mouse development. These genes are also mutated in several human birth defects, particularly those involving craniofacial abnormalities, and we are modeling these conditions in the mouse to analyze the underlying mechanistic causes of these human pathologies. Furthermore, we are now employing our experience studying the function of the AP-2 transcription factors as a springboard to begin a more systematic analysis into how transcription factors and signaling molecules regulate mouse embryonic development. In particular, we are studying the regulatory interactions between Fgf and Wnt signaling in the development of the mammalian body plan.