Molecular, Cell, Development (MCD) Seminar Series - McMaster University
2008-09 || 2009-10 || 2010-11 || 2011-12 || 2012-13

Molecular, Cell, Development (MCD) SEMINAR SERIES
Department of Biology

Speaker: Dr. Kristin Hope

Date: Friday 26th, October, 2012
Time: 12 noon
Location: HSC 1A5

Title: Dissecting the regulation of hematopoietic stem cell self-renewal

In lower organisms, cell polarization coupled with the asymmetric inheritance of fate determinants is critical for regenerating stem cell pools while simultaneously ensuring production of all required differentiated cell types. When dysregulated, these processes contribute instead towards malignant progression and the formation of tumours driven by stem cells that divide unchecked. Because of their importance in other stem cell systems, our work has looked to the potential role that polarity and asymmetric cell division proteins may play in the function of normal and/or malignant hematopoietic stem cells (HSC). Using an in vivo RNAi screen, 4 proteins with conserved roles in cell polarization and/or asymmetric cell division were identified as novel regulators of mouse HSCs. Of these, the RNA binding protein Musashi2 (Msi2) is of particular interest given its recent identification as a prognostic marker in human leukemia. This talk will highlight current efforts in the lab that focus on elucidating Msi2’s contribution to normal human hematopoietic function as well as understanding the molecular mechanisms through which Msi2 influences HSC self-renewal.