Molecular, Cell, Development (MCD) Seminar Series - McMaster University
2008-09 || 2009-10 || 2010-11 || 2011-12 || 2012-13

Molecular, Cell, Development (MCD) SEMINAR SERIES
Department of Biology


 
Speaker: Jessica Vanderploeg (Jacobs Lab, McMaster University)

Date: Friday, September 28, 2012
Time: 12 noon
Location: HSC 1A5

Title: A role for integrins in Drosophila cardial cell polarization and heart lumen formation

Abstract
In humans, disruptions in heart development are critical, as these can lead to congenital heart defects and other cardiovascular-related diseases. Since these diseases are multifactorial and complex, our lab uses Drosophila melanogaster (the fruit fly) as a genetic model to study heart development. Similar to vertebrate vasculogenesis, Drosophila embryonic heart development proceeds by cardiac progenitor cell specification, alignment, and migration, followed by cell polarization and lumen formation.

In this seminar, I will focus on our studies demonstrating a requirement for integrins and several integrin-related proteins in fly heart development. Presenting results from genetic and immunohistochemical based experiments, I will highlight several of the benefits and limitations of using Drosophila as a model for heart development.