Speaker: Justin Tong (Gupta Lab, McMaster University)
Date: Friday, September 14, 2012
Time: 12 noon
Location: HSC 1A5
Title: A Microfluidic Platform for Chemical Screening in C. elegans
Abstract
A method to induce and quantify on-demand locomotion in nematode Caenorhabditis elegans is here demonstrated in a novel assay for neurobehavioural chemical toxicity. We employ the assay in two contexts: a toxicological investigation of environmental pollutants, and a drug discovery screen of a compound library. Using electric fields and microfluidic technology, our assay is a rapid, sensitive, low-cost, and scalable technique to screen for factors affecting neuronal health.
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