Molecular, Cell, Development (MCD) Seminar Series - McMaster University
2008-09 || 2009-10 || 2010-11 || 2011-12 || 2012-13

Molecular, Cell, Development (MCD) SEMINAR SERIES
Department of Biology

Speaker: Dr. Marius Sudol (Staff Scientist, Weis Center for Research, Adjunct Associate Professor, Department of Medicine, The Mount Sinai School of Medicine, New York)

Date: Friday, August 31, 2012
Time: 12 noon
Location: HSC 1A5

Title: The Role of the WW Domain in Golabi Syndrome and Hippo Tumor Suppressor Pathway

WW domain is a small protein module that mediates well-defined protein-protein interactions. Missense mutations that map within the domain or its ligand were implicated in several human diseases, including Golabi-Ito-Hall and Liddle syndromes. In addition, a newly described Hippo tumor suppressor pathway uses many WW domain-containing proteins to regulate balance between proliferation and apoptosis. The seminar will review recent data on the molecular mechanism of the Golabi-Ito-Hall syndrome and on the Hippo tumor suppressor pathway. Both scenarios will be discussed from the molecular perspective of the WW domain. The ultimate goal of the discussed research is to predict and design molecular tools for interventions in WW domain- mediated pathways to correct pathological states.